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Liposomal Vitamin C

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China Joyful Nutritional Supply Co.,ltd
Joyful Nutritional Supply Co.,ltd
Joyful Nutritional is a ISO22000 verified leading manufacturer and solution provider of mineral ingredients including calcium, iron, zinc, selenium, and magnesium etc. Our production facility covers an area of 10,000 square meters and has several intelligent production lines and one testing laboratory approved by CNAS. We developed production and application technologies such as Microencapsulation, Activation, Embedding and lipidization, which solve and meet the unique needs of customers.
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01
FSSC22000 Food Safety Certified
The quality management system of Joyful Nutritional's production facility had been FSSC 22000 Verified
02
100000 ㎡ Production Area with 4 Production Lines
Our production facility covers an area of We have 4 Intelligent 100000 ㎡ with four intelligent production lines
03
CNAS Certified Laboratory
Joyful Nutritional is equipped with advanced laboratory certified by CNAS to ensure the products undergoes Rigorous Testing
04
Innovation in Solutions and Technology
Customized solutions including Microencapsulation,Dilution and Granulation,Emulsification,Microcrystals and embedding
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Latest company news about Highly Bioavailable Calcium Citrate Malate with A High Absorption Rate
2024-10-22

Highly Bioavailable Calcium Citrate Malate with A High Absorption Rate

  Highly Bioavailable Calcium Citrate Malate with A High Absorption Rate   1. What is Calcium Citrate Malate ?     Calcium Citrate Malate (CCM), also known as calcium citrate, is a neutral complex salt formed by malic acid, citric acid and calcium. The molecular formula and typical structure are shown in Figure 1.           2. Advantages of Calcium Citrate Malate compared to other calcium salts   1. Calcium Citate malate has the characteristics of high solubility, high absorption and utilization, safety and non-toxicity. Its water solubility is more than 100 times that of calcium carbonate and more than 10 times that of calcium citrate. Its aqueous solution is weakly acidic and its absorption and utilization rate is 37% higher than that of calcium carbonate.   2. Compared with calcium carbonate, calcium citrate malate as a calcium source does not consume gastric acid while supplementing calcium, and does not increase the risk of kidney stones.   3. Compared with other calcium nutritional enhancers, calcium citrate malate has the functions of supplementing calcium, enhancing bone density, regulating blood lipids, and enhancing oral health, reducing the risk of kidney stones, and not affecting the absorption of other trace elements.   4. Calcium citrate malate also has the physiological functions of malic acid such as anti-fatigue and heart protection. It can be used as a food additive and can also be directly made into calcium supplement health food, with broad development and application prospects.   3. High absorbability   The bioavailability of calcium refers to the proportion of calcium used by the body, which depends on many factors, including the number of "enhancing factors" and "hindering factors" and the acidity of the digestive environment. Studies have shown that malic acid and citric acid are the best absorbed substances for chelating minerals. Calcium is mainly absorbed in the duodenum, which is actively absorbed, and malic acid and citric acid are absorbed in the upper digestive tract. The biggest feature of calcium phosphate is that the human body has a high absorption rate of its calcium, and it also has high biological availability such as promoting bone formation and alleviating bone loss.       The high absorption of calcium hydroxyapatite has been confirmed by clinical experiments and animal experiments [2]. Miller et al. used single-label and double-label stable isotope technology to conduct clinical experiments on the calcium absorption rate of calcium carbonate and calcium hydroxyapatite. The calcium absorption rate of calcium hydroxyapatite reached (36.2±2.7)%, while the absorption rate of calcium carbonate was (26.4±2.2)%.   Wang Ling et al. [3] studied the effects of different calcium sources (calcium citrate malate group, solid calcium carbonate group, liquid calcium carbonate group, solid calcium carbonate plus vitamin D3 group and low calcium control group) on rat bone metabolism. Through the test results of six indicators including serum alkaline phosphatase, serum tartrate-resistant acid phosphatase, serum calcium, serum phosphorus, bone calcium and bone density, calcium citrate malate and solid calcium carbonate plus vitamin D3 had better effects on improving rat bone metabolism, indicating that organic acids and vitamin D3 can effectively promote calcium absorption.   Rzymski et al. [4] administered oral calcium pyruvate, calcium citrate malate, calcium carbonate, and placebo to 12 healthy postmenopausal women who had fasted before the intervention. They observed an increase in calcium levels within 180 minutes after ingestion, with calcium citrate malate providing the highest calcium levels (Figure 2).       Figure 2 Changes in serum calcium concentration after taking placebo or 1000 mg of different calcium sources   4. Little inhibitory effect on iron absorption   People mostly focus on supplementing a single dose of nutrients. When calcium and iron are taken at the same time, their interaction is often ignored. Hallerg et al.’s research suggests that oral calcium supplementation has a significant inhibitory effect on iron absorption, and there is a dose-response relationship. Other studies have shown that the effect of calcium on iron absorption is related to the time interval between the two intakes, and the inhibitory effect when ingested at the same time The strongest; oral calcium supplementation may affect the absorption of dietary iron, reduce circulating iron, and affect red blood cell production due to iron deficiency [5].   Wu Meiyin et al.[5] discussed the effects of three commonly used calcium agents, calcium citrate malate (CCM), calcium carbonate (CaCO3), and bone calcium (BC), combined with ferrous fumarate (FF) on calcium and iron absorption. and bioavailability of three calcium supplements.   Experimental results show that the CCM/FF combination can significantly increase the hemoglobin content (see Table 1) and serum iron content (see Table 2) in rats with iron deficiency anemia, indicating that CCM has a small inhibitory effect on iron absorption. In addition, the area under the calcitonin curve (AUC) of CCM is higher than that of CaCO3 and BC, which indirectly reflects that the absorption rate of CCM is higher than that of other calcium agents.         References: [1]. Jing Yiwen, Zhang Qiao, Yang Xiuyun, et al. Determination of 25 elemental impurities in calcium citrate malate[J]. Journal of Pharmaceutical Analysis, 2023, 43(7): 1229-1237. [2]. Wu Junlin, Wu Qingping, Zhang Jumei, Research progress on the physiological effects of calcium citrate malate. Food Science, 2010. 31(7): pp. 333-337. [3]. Wang Ling, et al., Effects of different calcium sources on bone metabolism in rats. Food and Fermentation Technology, 2017. 53(3): pp. 29-32. [4]. Rzymski, P., et al., The bioavailability of calcium in the form of pyruvate, carbonate, citrate–malate in healthy postmenopausal women. European Food Research and Technology, 2016. 242(1): p. 45-50. [5]. Wu Meiyin, Chen Shaojie, Yan Xiao, Effects of different calcium supplements on calcium and iron absorption in rats with iron deficiency anemia. Food Industry Science and Technology, 2015. 36(17): pp. 371-374.
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Latest company news about Iron Liposomal with Enhanced Absorption and Increased Bioavailability
2024-10-07

Iron Liposomal with Enhanced Absorption and Increased Bioavailability

Iron Liposomal with Enhanced Absorption and Increased Bioavailability   Introduction to Liposomal Technology   Liposomal technology has emerged as a groundbreaking method in the field of nutrient delivery. At its core, a liposome is a microscopic vesicle made up of phospholipid bilayers that encapsulates active ingredients, protecting them from degradation while facilitating their absorption in the body. This innovative approach enhances the bioavailability of various nutrients, making them more effective in therapeutic applications.   Specification sheet of Iron Liposomal with 8% Iron Purity   Testing Item Standard Appearance, Smell and impurity White to light yellow Granular Free of peculiar smell and odor, corruption and mildew No impurity and black dots by naked eyes directly Moisture content ≤10% Iron Content 7.0-9.0% Lead ( Pb) ＜1.0 mg/kg Arsenic (As) ＜1.0 mg/kg Mercury ＜1.0 mg/kg Cadmium ＜0.5 mg/kg Total Aerobic mirobial Count ＜10000 cfu/g Yeast and Mould ＜100 cfu/g Escherichia. Coli Absent in 1 gram Enterobacteriaceae Absent in 0.1 gram Salmonella Absent in 30 gram Staphylococcus aureus Absent in 0.1 gram Particle Size 100% pass 60 mesh       Advantages of Liposomized Ferrous Pyrophosphate   Liposomized ferrous pyrophosphate is a specialized form of iron supplementation that offers several key benefits:   1. Enhanced Absorption The liposomal encapsulation significantly improves the absorption rate of iron in the gastrointestinal tract. This technology protects ferrous pyrophosphate from oxidative damage, allowing for better uptake into the bloodstream.   2. Increased Bioavailability Unlike traditional iron supplements, which often face challenges such as low solubility and gastrointestinal side effects, liposomal iron provides higher bioavailability. This means that more iron reaches systemic circulation, which is crucial for effective supplementation.   3. Reduced Gastrointestinal Discomfort Many individuals experience discomfort when taking conventional iron supplements. Liposomal technology minimizes this issue by ensuring a more gradual release of iron, which reduces the risk of irritation and digestive issues.   4. Targeted Delivery The encapsulation process allows for targeted delivery of iron to specific cells and tissues in need, enhancing its effectiveness in supporting overall health and wellness. Applications of Liposomal Iron Liposomal ferrous pyrophosphate has a wide range of applications in both preventive and therapeutic contexts:   1. Iron Deficiency Anemia This form of iron is particularly beneficial for individuals suffering from iron deficiency anemia. Its enhanced absorption and reduced side effects make it a preferable option for those requiring regular supplementation.   2. Athletic Performance Athletes often require higher iron levels to support energy production and overall performance. Liposomal iron can help meet these increased demands efficiently.   3. Pregnancy and Lactation Pregnant and lactating women have heightened iron needs. Liposomal iron can provide a safe and effective way to ensure adequate iron levels during these critical periods.   4. General Health and Well-being Incorporating liposomal ferrous pyrophosphate into daily wellness routines can help maintain optimal iron levels, supporting energy, cognitive function, and overall vitality.   Iron liposomal technology represents the ultimate advancement in iron supplementation, combining enhanced absorption and increased bioavailability. With its numerous advantages and broad applications, liposomal ferrous pyrophosphate stands out as a superior choice for those seeking effective iron support. Embracing this innovative technology can lead to improved health outcomes and a better quality of life      
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